Tobin M J, Jenouri G, Sackner M A
Respiration. 1983;44(6):419-24. doi: 10.1159/000194579.
Recent reports suggest that endogenously released endorphins may exert a modifying influence on respiratory center drive in patients with respiratory disease. In this report, we employed respiratory inductive plethysmography to noninvasively assess breathing patterns with particular attention to respiratory center drive as reflected by mean inspiratory flow. We studied 10 patients with documented chronic obstructive pulmonary disease (6 with hypercapnia and 4 with normocapnia) after treatment with placebo and the opiate antagonist, naloxone. No significant change in breathing pattern was observed in either patient group after treatment with placebo or naloxone, although individual patients displayed greater respiratory drive after naloxone than placebo. Therefore, endorphins do not exert a consistent influence on respiratory center output in patients with chronic obstructive pulmonary disease.
最近的报告表明，内源性释放的内啡肽可能对呼吸系统疾病患者的呼吸中枢驱动产生调节作用。在本报告中，我们采用呼吸感应体积描记法以无创方式评估呼吸模式，特别关注平均吸气流量所反映的呼吸中枢驱动。我们研究了10例确诊为慢性阻塞性肺疾病的患者（6例高碳酸血症患者和4例正常碳酸血症患者），在给予安慰剂和阿片类拮抗剂纳洛酮治疗后进行观察。在用安慰剂或纳洛酮治疗后，两组患者的呼吸模式均未观察到显著变化，尽管个别患者在使用纳洛酮后比使用安慰剂时表现出更强的呼吸驱动力。因此，内啡肽对慢性阻塞性肺疾病患者的呼吸中枢输出并没有一致的影响。
