Ceriello A, Dello Russo P, Zuccotti C, Florio A, Nazzaro S, Pietrantuono C, Rosato G B
Thromb Haemost. 1983 Oct 31;50(3):633-4.
Antithrombin III activity was moderately but significantly decreased in insulin dependent diabetics (p less than 0.005), while no difference has been found between the diabetic (n = 25) and control groups (n = 22) in antithrombin III plasma concentration. Moreover, antithrombin III activity was inversely correlated with glycosylated plasma proteins (r = 0.57; p less than 0.01). These data show that in diabetes there is a depressed biological activity of antithrombin III and suggest that this reflects nonenzymatic glycosylation of antithrombin III protein.
胰岛素依赖型糖尿病患者的抗凝血酶III活性中度但显著降低（p<0.005），而糖尿病组（n = 25）和对照组（n = 22）的抗凝血酶III血浆浓度无差异。此外，抗凝血酶III活性与糖化血浆蛋白呈负相关（r = 0.57；p<0.01）。这些数据表明，糖尿病患者存在抗凝血酶III生物活性降低的情况，提示这反映了抗凝血酶III蛋白的非酶糖基化。
