Ceriello A, Giugliano D, Quatraro A, Stante A, Consoli G, Dello Russo P, D'Onofrio F
Diabete Metab. 1987 Feb;13(1):16-9.
The effect of rapid daily variation of glycemia and labile HbA1 on both antithrombin III (ATIII) activity and plasma concentration in ten insulin dependent diabetics has been evaluated. The variations of both plasma glucose and labile HbA1 were inversely correlated to the alterations of ATIII activity (r = -0.71 and r = -0.73, respectively, p less than 0.001), while no change in ATIII plasma concentration was present. These data suggest a direct role of glucose in determining rapid alteration of ATIII biologic activity, in vivo, in diabetes, probably mediated by labile non-enzymatic glycation.
已评估了10名胰岛素依赖型糖尿病患者中血糖的每日快速变化及不稳定糖化血红蛋白（HbA1）对抗凝血酶III（ATIII）活性和血浆浓度的影响。血浆葡萄糖和不稳定HbA1的变化与ATIII活性的改变呈负相关（r分别为-0.71和-0.73，p<0.001），而ATIII血浆浓度无变化。这些数据表明，在糖尿病患者体内，葡萄糖在决定ATIII生物活性的快速改变中起直接作用，这可能由不稳定的非酶糖基化介导。
