舒必利给药对大鼠母体和胎儿血浆催乳素水平及胎儿生长的影响。

The effect of sulpiride administration on maternal and fetal plasma prolactin levels, and fetal growth in rats.

作者信息

Fukaya T, Furuhashi N, Kono H, Shinkawa O, Takahashi T, Suzuki M

出版信息

Tohoku J Exp Med. 1983 Nov;141(3):323-6. doi: 10.1620/tjem.141.323.

DOI:10.1620/tjem.141.323

Abstract

Pregnant Wistar rats were daily injected with 5 mg sulpiride into the peritoneal cavity starting on day 14 of gestation. Blood samples were obtained from the maternal carotid artery and fetal axillary vessels on day 20 of gestation. Serum prolactin (PRL) levels were determined by radioimmunoassay using a rat PRL RIA kit. The maternal serum and fetal plasma PRL levels were significantly higher in the sulpiride-treated group than in the saline control group. There was a significant positive correlation between fetal body weight and fetal plasma PRL level. These results suggest that sulpiride which reached the fetus stimulates fetal PRL secretion and that PRL may exert a growth-promoting effect on the fetus.

摘要

从妊娠第14天开始，每天给怀孕的Wistar大鼠腹腔注射5毫克舒必利。在妊娠第20天从母体颈动脉和胎儿腋窝血管采集血样。使用大鼠催乳素放射免疫分析试剂盒通过放射免疫分析法测定血清催乳素（PRL）水平。舒必利治疗组的母体血清和胎儿血浆PRL水平显著高于生理盐水对照组。胎儿体重与胎儿血浆PRL水平之间存在显著正相关。这些结果表明，到达胎儿体内的舒必利刺激胎儿PRL分泌，并且PRL可能对胎儿发挥促生长作用。