胎儿和新生仓鼠的血清催乳素水平及其与母体水平的关系。

Serum prolactin levels in fetal and neonatal hamsters and the relationship to maternal levels.

作者信息

Thompson S A, Terranova P F

出版信息

Proc Soc Exp Biol Med. 1975 Nov;150(2):461-5. doi: 10.3181/00379727-150-39056.

PMID:1208562

Abstract

Immunoreactive prolactin was measured by RIA in 13.5-15.5 day gestation fetal and 0.5-3.5 day neonatal hamster serum and found to significantly reflect rises and falls in maternal levels. On the average, fetal and neonatal levels were 37% of maternal prolactin serum levels. 125I-PRL injected into 13.5-15.5 day pregnant hamsters was demonstrated to cross the placenta and enter fetal circulation. Ten min after injection, fetal serum levels were calculated to be an average of 3.9% of the radioactivity recorded in maternal serum. There is a strong possibility that fetal prolactin serum levels may be, at least in part, attributed to a maternal source.

摘要

采用放射免疫分析法（RIA）测定了妊娠13.5 - 15.5天的胎仓鼠及出生0.5 - 3.5天的新生仓鼠血清中的免疫反应性催乳素，发现其能显著反映母体水平的升降。平均而言，胎儿和新生儿的水平为母体催乳素血清水平的37%。向妊娠13.5 - 15.5天的仓鼠注射125I - PRL后，证实其可穿过胎盘进入胎儿循环。注射后10分钟，计算得出胎儿血清水平平均为母体血清中记录放射性的3.9%。胎儿催乳素血清水平很有可能至少部分归因于母体来源。