一个大家族中导致血清脂质水平和血压变异性的因素。

Factors contributing to the variability in serum lipid levels and blood pressure in a large kindred.

作者信息

Marazita M L, Elston R C, Namboodiri K K, Hames C G

出版信息

Am J Epidemiol. 1983 Dec;118(6):806-17. doi: 10.1093/oxfordjournals.aje.a113699.

DOI:10.1093/oxfordjournals.aje.a113699

Abstract

A 267-member, five-generation Caucasian kindred, that was originally from Evans County, Georgia, and that had a high incidence of cardiovascular disease, was chosen for a study of factors that may make significant contributions to the observed variability in serum lipid levels and blood pressure. A total of 234 of the 240 living members of the family agreed to participate and were examined in the summer of 1978 either at a clinic in Claxton, Georgia, or in their homes. Total serum cholesterol, triglycerides, high density lipoprotein cholesterol, systolic and diastolic blood pressures, height, weight, and two skinfold thicknesses were transformed to natural logarithms, and then adjusted for significant age effects by polynomial regressions on age, separately for each sex. These adjusted variables were then regressed on behavioral traits such as cigarette smoking using a step-wise, multiple linear regression procedure to determine the best fitting linear models. For males, behavioral traits accounted for 41.39% (R2) of the variance in height, 15.01% in weight, 19.51% in subscapular skinfold, 30.28% in triceps skinfold, 10.19% in triglycerides, 8.25% in total cholesterol, 15.81% in high density lipoprotein cholesterol, 21.32% in systolic blood pressure, and 28.23% in diastolic blood pressure. For females, the behavioral traits accounted for 31.40% of the variance in height, 25.99% in weight, 15.80% in subscapular skinfold, 9.84% in triceps skinfold, 7.20% in triglycerides, 21.08% in total cholesterol, 16.69% in high density lipoprotein cholesterol, 9.91% in systolic blood pressure, and 1.55% in diastolic blood pressure.

摘要

选取了一个来自佐治亚州伊文斯县、有267名成员的五代高加索家族进行研究，该家族心血管疾病发病率较高，旨在研究可能对观察到的血清脂质水平和血压变异性有重大影响的因素。该家族240名在世成员中有234人同意参与研究，并于1978年夏天在佐治亚州克拉克斯顿的一家诊所或他们家中接受了检查。血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇、收缩压和舒张压、身高、体重以及两个皮褶厚度均转换为自然对数，然后通过对年龄进行多项式回归，分别针对每个性别调整显著的年龄效应。然后，使用逐步多元线性回归程序，将这些调整后的变量与吸烟等行为特征进行回归，以确定最佳拟合线性模型。对于男性，行为特征在身高变异中占41.39%（R²），在体重中占15.01%，在肩胛下皮褶中占19.51%，在肱三头肌皮褶中占30.28%，在甘油三酯中占10.19%，在总胆固醇中占8.25%，在高密度脂蛋白胆固醇中占15.81%，在收缩压中占21.32%，在舒张压中占28.23%。对于女性，行为特征在身高变异中占31.40%，在体重中占25.99%，在肩胛下皮褶中占15.80%，在肱三头肌皮褶中占9.84%，在甘油三酯中占7.20%，在总胆固醇中占21.08%，在高密度脂蛋白胆固醇中占16.69%，在收缩压中占9.91%，在舒张压中占1.55%。