Birmingham B, Dyer A R, Shekelle R B, Stamler J
Department of Community Health and Preventive Medicine, Northwestern University Medical School, Chicago, IL 60611.
J Clin Epidemiol. 1993 Mar;46(3):289-302. doi: 10.1016/0895-4356(93)90077-e.
Associations of indices of adiposity with cardiovascular risk factors were examined in 1860 middle aged men employed by the Western Electric Company in Chicago in 1960 and 1961. Body mass index and subscapular and triceps skinfolds were examined for associations with systolic and diastolic blood pressure, serum cholesterol, and post-load serum glucose. Correlations of study variables measured one year apart suggest that triceps and subscapular skinfold measurements are less reproducible than body mass index, but more reproducible than measurements of systolic and diastolic blood pressure and serum cholesterol. Associations with blood pressure were stronger for body mass index than for skinfolds, and subscapular skinfold was associated with blood pressure independently of triceps skinfold, as well as age, heart rate, alcohol intake, and family history of cardiovascular disease. Body mass index was also generally more strongly related to serum cholesterol than skinfold measurements. Triceps skinfold was more strongly related to serum cholesterol than subscapular skinfold based on average values for the variables in 1960-61, but subscapular skinfold was more strongly related to one-year change in serum cholesterol. Subscapular skinfold was as strongly related to serum glucose as body mass index. This association was also independent of triceps skinfold and other variables. These analyses demonstrate positive associations of subscapular skinfold, an index of central adiposity, with blood pressure and serum glucose levels. Associations of subscapular and triceps skinfolds with serum cholesterol levels were not consistent in the cross-sectional and longitudinal analyses and require further investigation.
1960年和1961年,在芝加哥西部电气公司工作的1860名中年男性中,研究了肥胖指数与心血管危险因素之间的关联。研究了体重指数、肩胛下和肱三头肌皮褶厚度与收缩压、舒张压、血清胆固醇和负荷后血清葡萄糖之间的关联。相隔一年测量的研究变量之间的相关性表明,肱三头肌和肩胛下皮褶厚度测量的可重复性低于体重指数,但高于收缩压、舒张压和血清胆固醇测量。体重指数与血压的关联比皮褶厚度更强,肩胛下皮褶厚度与血压的关联独立于肱三头肌皮褶厚度,以及年龄、心率、酒精摄入量和心血管疾病家族史。体重指数与血清胆固醇的关联通常也比皮褶厚度测量更强。根据1960 - 1961年变量的平均值,肱三头肌皮褶厚度与血清胆固醇的关联比肩胛下皮褶厚度更强,但肩胛下皮褶厚度与血清胆固醇的一年变化关联更强。肩胛下皮褶厚度与血清葡萄糖的关联与体重指数一样强。这种关联也独立于肱三头肌皮褶厚度和其他变量。这些分析表明,肩胛下皮褶厚度(一种中心性肥胖指数)与血压和血清葡萄糖水平呈正相关。肩胛下和肱三头肌皮褶厚度与血清胆固醇水平的关联在横断面和纵向分析中并不一致,需要进一步研究。