Kirchhoff M, Torp-Pedersen C, Hougaard K, Jacobsen T J, Sjøl A, Munch M, Tingleff J, Jørgensen T, Schroll M, Olsen M E
Glostrup Populations Studies, Glostrup University Hospital, Denmark.
J Clin Epidemiol. 1994 May;47(5):469-74. doi: 10.1016/0895-4356(94)90293-3.
A population survey was conducted on 3608 randomly selected Danes aged 30, 40, 50 and 60 years respectively. Of these, 3400 were not in medical treatment for arterial hypertension. The following parameters were investigated: sex, age, serum lipid levels (total cholesterol, HDL cholesterol, triglycerides), presence of diabetes mellitus, height, body mass index (BMI), and average daily consumption of coffee, tobacco and alcohol. Analysis with multiple linear regression showed that all variables with the exception of triglycerides, HDL cholesterol and height were significantly associated with systolic blood pressure. Likewise all factors except diabetes, triglycerides and height were significantly associated with diastolic blood pressure. Further analysis in which the effect of each parameter was corrected for by the effects of the remaining variables, demonstrated that apart from age and sex only BMI and high alcohol consumption were positively associated with differences in blood pressure greater than a few mmHg. However, the variation in both systolic and diastolic blood pressures was only partly accounted for by the parameters studied--in the covariates analysis R2 for systolic blood pressure was 0.28 and R2 for diastolic blood pressure was 0.30. In conclusion, this investigation demonstrated that blood pressure is relatively independent of other factors important in the development of cardiovascular disease. Of the above-mentioned factors with some influence on blood pressure only age, BMI and high alcohol consumption have potential clinical importance.
对3608名分别为30岁、40岁、50岁和60岁的随机抽取的丹麦人进行了一项人口调查。其中,3400人未接受动脉高血压治疗。研究了以下参数:性别、年龄、血脂水平(总胆固醇、高密度脂蛋白胆固醇、甘油三酯)、糖尿病的存在、身高、体重指数(BMI)以及咖啡、烟草和酒精的平均每日摄入量。多元线性回归分析表明,除甘油三酯、高密度脂蛋白胆固醇和身高外,所有变量均与收缩压显著相关。同样,除糖尿病、甘油三酯和身高外,所有因素均与舒张压显著相关。进一步分析中,通过其余变量的影响对每个参数的影响进行校正,结果表明,除年龄和性别外,只有BMI和高酒精摄入量与血压差异大于几毫米汞柱呈正相关。然而,收缩压和舒张压的变化仅部分由所研究的参数解释——在协变量分析中,收缩压的R2为0.28,舒张压的R2为0.30。总之,这项调查表明血压相对独立于心血管疾病发展中其他重要因素。在上述对血压有一定影响的因素中,只有年龄、BMI和高酒精摄入量具有潜在的临床重要性。