衰老过程中淋巴细胞和浆细胞内的脂褐素

Lipofuscin in lymphocytes and plasma cells in aging.

作者信息

Beregi E, Regius O

出版信息

Arch Gerontol Geriatr. 1983 Nov;2(3):229-35. doi: 10.1016/0167-4943(83)90026-2.

Abstract

The age-related changes in spleen and lymph node lymphocytes and plasma cells of Wistar rats and in the peripheral lymphocytes of healthy human individuals were examined. Similar changes were described in human and rat lymphocytes and plasma cells consisting of mitochondrial lesions. The cristae of the mitochondria disappeared and were replaced by myelin-like structure, lamellar structure, electron-dense and electron-translucent material. It is supposed that this material corresponds to lipofuscin.

摘要

研究了Wistar大鼠脾脏和淋巴结淋巴细胞及浆细胞以及健康人类个体外周淋巴细胞的年龄相关变化。在人和大鼠的淋巴细胞及浆细胞中描述了类似的变化，包括线粒体损伤。线粒体嵴消失，被髓鞘样结构、层状结构、电子致密和电子透明物质所取代。据推测，这种物质对应于脂褐素。