Borges M M, Paula-Barbosa M M, Volk B
Neurobiol Aging. 1986 Sep-Oct;7(5):347-55. doi: 10.1016/0197-4580(86)90161-2.
Previous investigations have suggested that chronic alcohol consumption accelerates a number of age-related changes in the cerebellar cortex and hippocampal formation. In the cerebellum, alcohol-feeding has been shown to accelerate the intracellular deposition of lipofuscin. In order to determine whether alcohol administration has a similar effect on hippocampal lipofuscin deposition, we studied the pattern of lipofuscin deposition in alcohol-fed rats for periods of 1, 3, 6, 12 and 18 months and compared the results with those obtained in the respective pair-fed controls. A precocious and progressive deposition of lipofuscin pigment was found in both CA1 and CA3 neurons in Ammon's horn hippocampal fields after 3 and 6 months of alcohol feeding, respectively. These results parallel those observed during normal aging and reinforce the hypothesis of a close link between chronic alcohol consumption and a premature nerve cell aging.
先前的研究表明，长期饮酒会加速小脑皮质和海马结构中一些与年龄相关的变化。在小脑中，已证实饮酒会加速脂褐素在细胞内的沉积。为了确定饮酒是否对海马脂褐素沉积有类似影响，我们研究了饮酒大鼠在1、3、6、12和18个月期间脂褐素沉积的模式，并将结果与相应的配对喂食对照组进行了比较。分别在饮酒3个月和6个月后，在海马齿状回CA1和CA3神经元中发现了脂褐素色素的早熟和渐进性沉积。这些结果与正常衰老过程中观察到的结果相似，并强化了长期饮酒与神经细胞过早衰老之间存在密切联系的假设。
