Jonassen F, Granerus G, Wetterqvist H
Acta Obstet Gynecol Scand. 1976;55(5):387-94. doi: 10.3109/00016347609158521.
Oral combined contraceptives did not seem to alter histamine metabolism in females. During treatment with gonadotrophic hormones in four amenorrhoeic patients there was a tendency towards increasing excretion of methylhistamine (MeHi) followed by a sudden decrease corresponding to changes in the urinary estrogen. The excretion of methylimidazoleacetic acid (MeImAA) seemed to parallel that of MeHi. The findings support the hypothesis that an endogenous surge of estrogen may influence histamine turnover in women. Women of post-menopausal age have about the same histamine metabolism as younger menstruating women. Estrogen medication relieved symptoms of hot flushes or sweats but did not seem to affect the histamine turnover.
口服复方避孕药似乎不会改变女性体内的组胺代谢。在对四名闭经患者使用促性腺激素治疗期间，甲基组胺（MeHi）的排泄量有增加的趋势，随后随着尿雌激素的变化而突然下降。甲基咪唑乙酸（MeImAA）的排泄量似乎与MeHi平行。这些发现支持了内源性雌激素激增可能影响女性组胺代谢的假说。绝经后女性的组胺代谢与年轻的有月经的女性大致相同。雌激素药物缓解了潮热或盗汗症状，但似乎并未影响组胺代谢。
