Besa E C, Wolff S M, Dale D C, Gardner F H
Lancet. 1977 Apr 2;1(8014):728-30. doi: 10.1016/s0140-6736(77)92170-5.
Ten patients with bone-marrow failure from myelofibrosis, aplastic anaemia, paroxysmal nocturnal haemoglobinuria, and "hairy cell" leukaemia, who had failed to respond to androgens and/or glucocorticosteroids, were treated with a combination of aetiocholanolone and prednisolone. All patients except one with aplastic anaemia responded with an increase in reticulocytes, haematocrit, red blood cell mass, and blood neutrophils and platelets. These data suggest that aetiocholanolone, and similar 5beta-hydroxy steroids, may be valuable in treating certain patients with chronic marrow failure.
10名患有骨髓纤维化、再生障碍性贫血、阵发性夜间血红蛋白尿和“毛细胞”白血病导致骨髓衰竭的患者，对雄激素和/或糖皮质激素治疗无效，接受了本胆烷醇酮和泼尼松龙联合治疗。除1例再生障碍性贫血患者外，所有患者的网织红细胞、血细胞比容、红细胞量、血液中性粒细胞和血小板均有所增加。这些数据表明，本胆烷醇酮以及类似的5β-羟基类固醇可能对治疗某些慢性骨髓衰竭患者有价值。
