Gardner F H, Juneja H S
Br J Haematol. 1987 Mar;65(3):295-300. doi: 10.1111/j.1365-2141.1987.tb06856.x.
During the past 9 years, 43 adult patients with severe aplastic anaemia have been treated with a combination of 3 alpha etiocholanolone and nandrolone decanoate in an uncontrolled pilot study. Eleven patients were considered acute and the remainder as chronic severe aplasia. 50% (22 patients) had a haematopoietic recovery and 40% have had a sustained remission varying from 1.5 to 8 years. Three patients who did not respond to 3 alpha etiocholanolone had a haematologic response when treated with the isomer 3 beta etiocholanolone. The recovery did not appear to be associated with age or duration of marrow aplasia. In view of the reproducible chemical structure of these androstanes, we believe this group of steroids should be evaluated further in the treatment of severe aplastic anaemia.
在过去9年中，一项非对照的初步研究对43例成年重型再生障碍性贫血患者采用3α-表雄酮和癸酸诺龙联合治疗。11例患者为急性型，其余为慢性重型再生障碍性贫血。50%（22例患者）出现造血恢复，40%获得了持续缓解，缓解期为1.5至8年不等。3例对3α-表雄酮无反应的患者在接受异构体3β-表雄酮治疗时出现血液学反应。恢复情况似乎与年龄或骨髓再生障碍的持续时间无关。鉴于这些雄烷类化合物具有可重复的化学结构，我们认为这类甾体激素在重型再生障碍性贫血的治疗中应进一步评估。
