Seewald T R, Zeigler Z R, Gardner F H
Department of Medicine, Montefiore Hospital, University of Pittsburgh School of Medicine, PA 15213.
Am J Hematol. 1989 Jul;31(3):216-8. doi: 10.1002/ajh.2830310315.
A patient with aplastic anemia, who had been unresponsive to androgens, antithymocyte globulin, high-dose methylprednisolone, and cyclosporine, responded to treatment with 3-beta-etiocholanolone, nandrolone decanoate, and prednisolone acetate. Six months following initiation of therapy, she became red cell and platelet transfusion independent with neutrophils persistently over 1,000/microliters. A sustained partial remission has persisted for over 2 years. This observation suggests that a combined hematostimulatory approach may be of benefit, even in patients with long-standing refractory aplasia.
一名再生障碍性贫血患者，对雄激素、抗胸腺细胞球蛋白、大剂量甲泼尼龙和环孢素治疗均无反应，却对3-β-乙基胆甾烷醇酮、癸酸诺龙和醋酸泼尼松龙治疗有反应。治疗开始6个月后，她不再依赖红细胞和血小板输血，中性粒细胞持续超过1000/微升。持续部分缓解状态已持续2年多。这一观察结果表明，即使是长期难治性再生障碍性贫血患者，联合造血刺激方法可能有益。
