Zorick F, Roehrs T, Conway W, Fujita S, Wittig R, Roth T
Bull Eur Physiopathol Respir. 1983 Nov-Dec;19(6):600-3.
Pre- and post-treatment nocturnal polysomnography and multiple sleep latency tests (MSLT) were done in thirty-one patients with obstructive sleep apnea syndrome who underwent uvulopalatopharyngoplasty. The treatment reduced by half the frequency of apneas and hypoxemia occurring during sleep and improved the excessive daytime sleepiness, but not all patients responded similarly. Among patients classified as responders, the frequency of apnea was reduced to a level seen in healthy adults of the same age, measures of sleep approached normal, and excessive sleepiness was eliminated. In nonresponders, frequency of apneas and consequent disruption of sleep was not reduced, but hypoxemia was improved. The MSLT differentiated responders from nonresponders who showed no MSLT improvement, although 70% reported a subjective improvement in excessive sleepiness. Measures of the apneas' disruptive effect on sleep and not its hypoxemic consequences were most predictive of improvement in excessive sleepiness.
对31例接受悬雍垂腭咽成形术的阻塞性睡眠呼吸暂停综合征患者进行了治疗前和治疗后的夜间多导睡眠图及多次睡眠潜伏期测试（MSLT）。治疗使睡眠期间发生的呼吸暂停和低氧血症频率减半，并改善了日间过度嗜睡，但并非所有患者的反应都相似。在被归类为反应者的患者中，呼吸暂停频率降至同年龄健康成年人的水平，睡眠指标接近正常，过度嗜睡也消除了。在无反应者中，呼吸暂停频率和随之而来的睡眠中断并未降低，但低氧血症有所改善。MSLT能够区分反应者和无反应者（无反应者的MSLT无改善），尽管70%的患者报告主观上过度嗜睡有所改善。呼吸暂停对睡眠的干扰作用而非其低氧血症后果的指标最能预测过度嗜睡的改善情况。
