Gilbert R J
Br J Pharmacol. 1983 Sep;80(1):133-9. doi: 10.1111/j.1476-5381.1983.tb11058.x.
After intramuscular injection of 3.5 mg kg-1 to rabbits, diminazene aceturate shows biphasic pharmacokinetics with maximum blood and interstitial fluid concentrations occurring after 15 min and 3 h respectively. Seven days after treatment, 40-50% of the dose had been excreted in the urine and 8-20% in faeces. Highest diminazene residues were determined in liver: 7 days after dosage, residues of 40.53 +/- 4.00 micrograms g-1 were present, corresponding to 35-50% of the dose. The recommended dose of 3.5 mg kg-1 was not curative for Trypanosoma congolense infections of rabbit but did cause the parasitaemia to become subpatent. A limited prophylactic effect was observed.
给兔子肌肉注射3.5毫克/千克乙酰氨基阿维菌素后，其呈现双相药代动力学，血药浓度和组织液浓度分别在15分钟和3小时后达到最大值。治疗7天后，40 - 50%的剂量经尿液排出，8 - 20%经粪便排出。肝脏中检测到最高的乙酰氨基阿维菌素残留：给药7天后，残留量为40.53±4.00微克/克，相当于剂量的35 - 50%。推荐剂量3.5毫克/千克对兔刚果锥虫感染没有治疗效果，但确实使寄生虫血症变为隐性。观察到有限的预防作用。
