血小板激活因子对豚鼠离体心脏标本的作用。
The actions of Paf-acether (platelet-activating factor) on guinea-pig isolated heart preparations.
作者信息
Benveniste J, Boullet C, Brink C, Labat C
出版信息
Br J Pharmacol. 1983 Sep;80(1):81-3. doi: 10.1111/j.1476-5381.1983.tb11052.x.
Abstract
Paf-acether (platelet-activating factor) is a phospholipid capable of stimulating platelets to release their granular contents and cause platelet aggregation. When Paf-acether was administered to isolated heart preparations from normal guinea-pigs there was a significant concentration-dependent reduction in coronary flow and contractile force. The high concentration of Paf-acether was equally effective in reducing these cardiac parameters in the presence of atropine. The non-acetylated Paf-acether analogue, 2-lyso Paf-acether, the enantiomer, and a closely related phospholipid 1, alpha-lysophosphatidylcholine palmitoyl, did not affect coronary flow and contractile force, indicating the specificity of Paf-acether. These data demonstrate a potent effect of Paf-acether on cardiac function. Whether or not these effects are direct or mediated through generation of endogenous mediators remains to be established.
摘要
血小板激活因子（Paf-乙酰醚）是一种磷脂，能够刺激血小板释放其颗粒内容物并引起血小板聚集。当将血小板激活因子施用于正常豚鼠的离体心脏制剂时，冠状动脉血流量和收缩力会出现显著的浓度依赖性降低。在阿托品存在的情况下，高浓度的血小板激活因子在降低这些心脏参数方面同样有效。非乙酰化的血小板激活因子类似物2-溶血血小板激活因子、对映体以及密切相关的磷脂1-α-溶血磷脂酰胆碱棕榈酸酯均不影响冠状动脉血流量和收缩力，这表明了血小板激活因子的特异性。这些数据证明了血小板激活因子对心脏功能有强大作用。这些作用是直接的还是通过内源性介质的产生介导的，仍有待确定。
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本文引用的文献
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[Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine].[血小板激活因子（PAF）的半合成及推测结构：PAF-乙酰乙醚，溶血磷脂酰胆碱的烷基醚类似物]
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