Beynon L L, Busuttil A, Newsam J E, Chisholm G D
Br J Urol. 1983 Dec;55(6):733-6. doi: 10.1111/j.1464-410x.1983.tb03415.x.
Fifty-one of 212 consecutive patients with prostatic cancer presented with incidentally diagnosed (TO) cancer. The average age at presentation was 73 years and follow-up ranged from 1 to 62 months. Deferred treatment was selected in 39 cases, 10 of which progressed. Of 15 deaths only 3 were related to prostate cancer and these were patients who had presented with metastases. Histological grading by the Gleason system demonstrated a significant correlation with metastatic stage at presentation and tumour bulk, but not with age or progression in deferred treatment cases. It is concluded that there is a need to subdivide patients presenting with incidental carcinoma, that tumour bulk correlates with histological grade and that future treatment protocols for TO disease should stratify for histological grade.
在212例连续性前列腺癌患者中，有51例为偶然诊断出的（T0期）癌症。确诊时的平均年龄为73岁，随访时间为1至62个月。39例患者选择了延迟治疗，其中10例病情进展。15例死亡病例中，只有3例与前列腺癌相关，且这些患者均已出现转移。根据Gleason系统进行的组织学分级显示，其与确诊时的转移分期和肿瘤体积显著相关，但与年龄或延迟治疗病例的病情进展无关。结论是，有必要对偶然癌患者进行细分，肿瘤体积与组织学分级相关，未来针对T0期疾病的治疗方案应根据组织学分级进行分层。
