Goodman C M, Busuttil A, Chisholm G D
University Department of Surgery/Urology, Western General Hospital, Edinburgh.
Br J Urol. 1988 Dec;62(6):576-80. doi: 10.1111/j.1464-410x.1988.tb04429.x.
Of 403 consecutive cases of prostatic carcinoma 69 were diagnosed incidentally and were managed with a deferred treatment policy. The mean age at diagnosis was 74 years and mean follow-up was 42 months. Retrospective analysis confirmed that many such patients die of intercurrent disease before symptomatic tumour progression. However, patients aged 70 years or less at diagnosis with diffuse, high grade disease were shown to be at greater risk of symptomatic tumour progression. In this study 60% progressed to skeletal metastases within 3 years. Deferral of treatment in such patients appears inappropriate.
在403例连续的前列腺癌病例中，69例是偶然诊断出来的，并采用了延迟治疗策略。诊断时的平均年龄为74岁，平均随访时间为42个月。回顾性分析证实，许多此类患者在有症状的肿瘤进展之前死于并发疾病。然而，诊断时年龄在70岁及以下且患有弥漫性、高级别疾病的患者，有症状的肿瘤进展风险更高。在本研究中，60%的患者在3年内进展为骨转移。对这些患者延迟治疗似乎不合适。
