Rogawski M A, Barker J L
Brain Res. 1983 Nov 28;280(1):180-5. doi: 10.1016/0006-8993(83)91190-3.
We examined the effects of 4-aminopyridine (4-AP) on calcium conductance mechanisms in cultured mouse spinal cord neurons. At low concentrations (less than or equal to 1 mM), 4-AP enhanced Ca2+-dependent transmitter release and prolonged the duration of Ca2+-dependent action potentials. Voltage clamp studies indicated that 4-AP directly facilitates Ca2+ entry through voltage sensitive channels apart from an effect on K+ currents. These results may help to explain why the drug promotes Ca2+-dependent transmitter release at peripheral and central synapses.
我们研究了4-氨基吡啶（4-AP）对培养的小鼠脊髓神经元钙电导机制的影响。在低浓度（小于或等于1 mM）时，4-AP增强了Ca2+依赖性递质释放，并延长了Ca2+依赖性动作电位的持续时间。电压钳研究表明，4-AP除了对K+电流有影响外，还直接促进Ca2+通过电压敏感通道进入。这些结果可能有助于解释为什么该药物在外周和中枢突触处促进Ca2+依赖性递质释放。
