血卟啉衍生物光辐射疗法治疗小鼠实体瘤

Hematoporphyrin derivative photoradiation therapy in murine solid tumors.

作者信息

Canti G, Ricci L, Cantone V, Franco P, Marelli O, Andreoni A, Cubeddu R, Nicolin A

出版信息

Cancer Lett. 1983 Dec;21(2):233-7. doi: 10.1016/0304-3835(83)90212-4.

Abstract

The cytocidal activity of light-activated hematoporphyrin derivative (Hpd) in experimental and human tumors is under investigation in many laboratories. This activity is based upon preferential incorporation of Hpd in malignant tissues and its photosensibilization by red light. Treatment of mice bearing MS-2 fibrosarcoma and B16 melanoma, a metastastic tumor, with Hpd and laser light, externally or delivered through a quartz fiber optic imbedded directly into the tumor, significantly prolonged the median survival time. This therapy was compared with surgical excision of primary tumors, and preliminary results on metastatic neoplasm suggest that the photoradiation therapy is more effective than surgery.

摘要

许多实验室正在研究光激活血卟啉衍生物（Hpd）在实验性肿瘤和人类肿瘤中的细胞杀伤活性。这种活性基于Hpd在恶性组织中的优先摄取及其被红光的光敏化作用。用Hpd和激光对携带MS-2纤维肉瘤和转移性肿瘤B16黑色素瘤的小鼠进行治疗，无论是通过外部照射还是通过直接植入肿瘤的石英光纤进行照射，均显著延长了中位生存时间。将这种疗法与原发性肿瘤的手术切除进行了比较，关于转移性肿瘤的初步结果表明，光辐射疗法比手术更有效。