Secreto G, Recchione C, Grignolio E, Cavalleri A
Cancer Detect Prev. 1983;6(4-5):435-8.
Six patients who developed breast cancer between the ages of 27 and 55 years had been examined for their urinary excretion of testosterone and androstanediol 17 to 69 months before the clinical onset of their cancer. Each of them showed higher than normal excretion values of testosterone or androstanediol, or both. At the time of hormonal examination, the patients were considered at risk for breast cancer because their history had included one or more of the following factors: previous mammary disease, familiality, sterility or subfertility, menstrual cycle irregularities. On the basis of this evidence, it would seem that high androgenic activity is a risk factor for developing breast cancer in patients with the "adverse" history.
6名年龄在27至55岁之间患乳腺癌的患者，在其癌症临床发病前17至69个月接受了睾酮和雄烷二醇尿排泄检测。他们每个人的睾酮或雄烷二醇排泄值都高于正常水平，或两者皆高。在进行激素检测时，这些患者被认为有患乳腺癌的风险，因为他们的病史包括以下一个或多个因素：既往乳腺疾病、家族性、不育或生育力低下、月经周期不规律。基于这一证据，高雄激素活性似乎是有“不良”病史患者患乳腺癌的一个风险因素。
