Doberne Y, New M I
J Clin Endocrinol Metab. 1976 Jan;42(1):152-4. doi: 10.1210/jcem-42-1-152.
Data are presented on the daily urinary excretion of androstanediol and testosterone in healthy adults using a sensitive radioligand assay. In nine men, the average urinary androstanediol (79 mug/day) was not significantly different from the urinary testosterone (84 mug/day). However, in women the average values of urinary androstanediol excretion (12 mug/day) were significantly higher than the urinary testosterone (4.2 mug/day). In each of the females, the urinary androstanediol was greater than the urinary testosterone. The data do not support the hypothesis that the daily urinary androstanediol excretion is a measure of the 5alpha-reduction of testosterone in androgen target tissues.
使用灵敏的放射性配体分析法呈现了健康成年人每日尿中雄烷二醇和睾酮排泄的数据。在9名男性中，尿中雄烷二醇的平均排泄量（79微克/天）与尿睾酮（84微克/天）无显著差异。然而，女性尿中雄烷二醇的平均排泄量（12微克/天）显著高于尿睾酮（4.2微克/天）。在每一名女性中，尿中雄烷二醇均高于尿睾酮。这些数据不支持每日尿中雄烷二醇排泄量是雄激素靶组织中睾酮5α-还原量指标的假说。
