Gratterola R
Cancer Res. 1978 Sep;38(9):3051-4.
The urine of 26 otherwise healthy women with fibrocystic disease of the breast was assayed by gas chromatography for testosterone and androstanediol (5alpha-androstane-3alpha, 17beta-diol), the major metabolite of dihydrotestosterone. The mean values for both androgens were significantly higher than in 18 normal women in the same age range. Sixteen of the 26 fibrocystic disease patients also had endometrial hyperplasia. Since the endometrial specimen was obtained in the premenstrual period, the presence of hyperplasia proved that the menstrual cycle in over two-thirds of the fibrocystic disease patients was nonovulatory.
对26名患有乳腺纤维囊性疾病但其他方面健康的女性的尿液进行气相色谱分析，以检测睾酮和雄烷二醇（5α-雄烷-3α，17β-二醇），后者是双氢睾酮的主要代谢产物。这两种雄激素的平均值显著高于同一年龄段的18名正常女性。26名纤维囊性疾病患者中有16名同时患有子宫内膜增生。由于子宫内膜样本是在经前期采集的，增生的存在证明超过三分之二的纤维囊性疾病患者的月经周期无排卵。
