一种用于个体化苯妥英钠剂量的新型可编程计算器程序。

A new programmable calculator procedure for individualizing phenytoin dosage.

作者信息

Messori A, Valenza T, Zaccara G, Arnetoli G, Bartoli C, Donati-Cori G, Tendi E, Zappoli R

出版信息

Drug Intell Clin Pharm. 1983 Dec;17(12):890-3. doi: 10.1177/106002808301701203.

Abstract

A programmable calculator procedure allowing nonlinear least-squares fit to pharmacokinetic data conforming to the Michaelis-Menten model is described. Model parameter estimation is performed according to the iterative Gauss-Newton technique as modified by Hartley. This procedure thus employs the same theoretical approach used by most pharmacokinetic computer programs. No programming skill is needed to run the program described. The proposed procedure is discussed in detail and applied to some sets of pharmacokinetic data.

摘要

描述了一种可编程计算器程序，该程序可对符合米氏模型的药代动力学数据进行非线性最小二乘拟合。模型参数估计是根据哈特利修改后的迭代高斯-牛顿技术进行的。因此，该程序采用了大多数药代动力学计算机程序所使用的相同理论方法。运行所描述的程序不需要编程技能。对所提出的程序进行了详细讨论，并将其应用于几组药代动力学数据。