Nickel O, Lindner P, Schad N
Eur J Nucl Med. 1983;8(10):431-5. doi: 10.1007/BF00252941.
The use of the short-lived (30 s) isotope 195mAu in brain perfusion studies has been tested on 40 patients and 8 volunteers. The activity of the eluate from the 195mHg/195Au generator was high enough to give good image statistics of brain perfusion after a single bolus injection. The examinations can be repeated after 3 min giving the same quality and without significant background. The use of a low-energy photon peak at 68 keV (Au-K alpha) allows the imaging of brain perfusion in both lateral views with almost no look-through effect. With a modified height-over-area formula for the calculation of regional cerebral blood flow parametric images were obtained of high diagnostic value. The sensitivity and reproducibility of the method has been demonstrated by mental stimulation tests on eight volunteers: after optical stimulation a clear increase of blood flow could be shown in the visual cortex.
已对40名患者和8名志愿者进行了在脑灌注研究中使用半衰期短（30秒）的同位素195mAu的测试。来自195mHg/195Au发生器的洗脱液活性足够高，在单次团注注射后能给出良好的脑灌注图像统计数据。3分钟后可重复检查，图像质量相同且背景无明显增加。使用68keV（金-Kα）的低能光子峰能够在两个侧位视图中对脑灌注进行成像，几乎没有穿透效应。通过修改后的高度与面积公式计算区域脑血流，获得了具有高诊断价值的参数图像。通过对8名志愿者进行精神刺激测试证明了该方法的敏感性和可重复性：在视觉刺激后，视觉皮层的血流明显增加。
