Rozenfeld D, Wolfson L I
Semin Nucl Med. 1981 Jul;11(3):172-85. doi: 10.1016/s0001-2998(81)80002-5.
Regional cerebral blood flow (r-CBF) can be measured using 133XE and collimated detectors. The radionuclide can be administered either by inhalation or intracarotid injection. Comparison of blood flow determinations at rest and during performance of an activity identifies those brain regions that become active during the performance of the activity. Relatively specific patterns of r-CBF are observed during hand movements, sensory stimulation, eye movements, speech, listening, and reading. Regional CBF changes during reasoning and memorization are less specific and less well characterized. It is clear that brain lesions affect r-CBF responses to various activities, but this effect has not been well correlated with functional deficits or recovery of function. Regional CBF measurement gives information about brain activity and the functional response to experimental manipulation. This approach may well add to our understanding of normal, as well as pathologic, brain functioning.
局部脑血流量（r-CBF）可用133氙和准直探测器进行测量。放射性核素可通过吸入或颈内动脉注射给药。比较静息状态和活动期间的血流测定结果，可确定在活动过程中变得活跃的那些脑区。在手运动、感觉刺激、眼球运动、言语、听力和阅读过程中观察到相对特定的r-CBF模式。推理和记忆过程中局部脑血流量的变化不太特异，特征也不太明显。显然，脑损伤会影响r-CBF对各种活动的反应，但这种影响与功能缺陷或功能恢复并未很好地关联。局部脑血流量测量可提供有关脑活动以及对实验操作的功能反应的信息。这种方法很可能会增进我们对正常以及病理脑功能的理解。
