γ-氨基丁酸、巴氯芬和加巴喷丁对兔尾状核多巴胺释放的抑制作用：作用位点相同还是不同？

Inhibition by GABA, baclofen and gabapentin of dopamine release from rabbit caudate nucleus: are there common or different sites of action?

作者信息

Reimann W

出版信息

Eur J Pharmacol. 1983 Oct 28;94(3-4):341-4. doi: 10.1016/0014-2999(83)90425-9.

Abstract

Slices of rabbit caudate nucleus were preincubated with [3H]dopamine then superfused and stimulated electrically. Baclofen, GABA and gabapentin 10(-4) and 10(-3) mol/l reduced the stimulation-evoked overflow of tritium in a similar manner. The effects of the substances were reinvestigated while one of them was present in a high concentration throughout the superfusion. These interaction experiments showed that baclofen and GABA have a common presynaptic site of action which is different from that of gabapentin.

摘要

将兔尾状核切片先用[3H]多巴胺预孵育，然后进行灌流并给予电刺激。10(-4)和10(-3)mol/L的巴氯芬、γ-氨基丁酸（GABA）和加巴喷丁以相似的方式减少了刺激诱发的氚溢出。当其中一种物质在整个灌流过程中以高浓度存在时，对这些物质的作用进行了重新研究。这些相互作用实验表明，巴氯芬和GABA有一个共同的突触前作用位点，该位点与加巴喷丁的不同。