Nutrition Department, National Veterinary School of Toulouse (ENVT), Toulouse, France.
Anaesthesia Department, National Veterinary School of Toulouse (ENVT), Toulouse, France.
J Feline Med Surg. 2020 Dec;22(12):1176-1183. doi: 10.1177/1098612X20916391. Epub 2020 May 28.
The aim of the study was to evaluate the appetite-stimulating effect of gabapentin by comparing it with mirtazapine in healthy cats in the first 8 h after ovariectomy surgery.
This double-masked, placebo-controlled, prospective clinical trial included 60 healthy cats presented to the hospital for ovariectomy: 20 received gabapentin, 21 received mirtazapine and 19 received a placebo immediately before and 6 h after surgery. Food was offered at 2, 4, 6 and 8 h post-ovariectomy. After each meal, food intake was measured. Data were analysed using repeated-measure ANOVA and a linear mixed-model analysis. Post-hoc Tukey's honest significant difference test was performed for multiple comparisons.
Food intake increased in both treatment groups vs placebo. No statistically significant difference was found between cats treated with gabapentin or mirtazapine.
Cats receiving gabapentin ate more than cats in the placebo group. Thirty percent of cats in the gabapentin group covered their resting energy requirements, while none of the cats in the placebo group did. Gabapentin and mirtazapine produced similar effects on food intake.
本研究旨在通过比较加巴喷丁和米氮平在去卵巢手术后 8 小时内对健康猫的食欲刺激作用，评估加巴喷丁的作用。
这是一项双盲、安慰剂对照、前瞻性临床试验，纳入了 60 只因去卵巢术而就诊于医院的健康猫：20 只接受加巴喷丁治疗，21 只接受米氮平治疗，19 只接受安慰剂治疗，分别在术前和术后 6 小时内给予。在去卵巢术后 2、4、6 和 8 小时提供食物。每次进食后，测量食物摄入量。使用重复测量方差分析和线性混合模型分析对数据进行分析。对于多重比较，进行了事后 Tukey 诚实显著差异检验。
与安慰剂组相比，两组治疗组的食物摄入量均增加。接受加巴喷丁或米氮平治疗的猫之间没有统计学上的显著差异。
接受加巴喷丁治疗的猫比安慰剂组的猫吃得更多。30%的加巴喷丁组猫满足了其静息能量需求，而安慰剂组的猫没有。加巴喷丁和米氮平对食物摄入有相似的影响。
