Lebedev A A
Farmakol Toksikol. 1983 Nov-Dec;46(6):79-83.
The mercuric-xanthine diuretic novurit, ethacrynic acid and furosemide reduced the fluorescence of 1,8-anilinonaphthalene-8-sulfonate (1,8-ANS) in a suspension of phospholipid liposomes and human serum albumin solution. Ethacrynic acid and furosemide eliminated the fluorescence of 1,8-ANS in a suspension of non-energized mitochondria of rat kidney, while novurit provoked fluorescence intensification. The constants of novurit and ethacrynic acid binding with kidney mitochondria determined by the degree of changes in 1,8-ANS fluorescence variation appeared significantly higher than the constants of binding with phospholipids and serum albumin. However furosemide did not show a predominant binding with kidney mitochondria.
汞黄嘌呤利尿剂诺武利特、依他尼酸和呋塞米降低了磷脂脂质体悬浮液和人血清白蛋白溶液中1,8-苯胺基萘-8-磺酸盐（1,8-ANS）的荧光。依他尼酸和呋塞米消除了大鼠肾脏非活性线粒体悬浮液中1,8-ANS的荧光，而诺武利特则引起荧光增强。根据1,8-ANS荧光变化程度确定的诺武利特和依他尼酸与肾线粒体的结合常数明显高于与磷脂和血清白蛋白的结合常数。然而，呋塞米与肾线粒体没有显示出主要的结合。
