Wennberg R P, Rasmussen F, Ahlfors C E
J Pediatr. 1977 Apr;90(4):647-50. doi: 10.1016/s0022-3476(77)80393-4.
The interaction of three diuretics with bilirubin-albumin complexes was studied using the peroxidase assay, erythrocyte uptake, and sephadex gel filtration. On a molar basis, each diuretic was as potent or more potent than sulfisoxazole in displacing bilirubin from albumin. Furosemide and ethacrynic acid, when used at the recommended dosage (1 mg/kg), would probably not produce a significant increase in free bilirubin in most infants. Chlorothiazide could introduce a significant risk to jaundiced infants because of the higher dosage required.
使用过氧化物酶测定法、红细胞摄取法和葡聚糖凝胶过滤法研究了三种利尿剂与胆红素-白蛋白复合物的相互作用。以摩尔为基础，每种利尿剂在从白蛋白置换胆红素方面与磺胺异恶唑一样有效或更有效。当按推荐剂量（1毫克/千克）使用时，速尿和依他尼酸在大多数婴儿中可能不会使游离胆红素显著增加。由于所需剂量较高，氯噻嗪可能会给黄疸婴儿带来重大风险。
