杂环酰基胆碱的合成与生物活性
Synthesis and biological activity of heterocyclic acyl-cholines.
作者信息
De Micheli C, De Amici M, Santagostino Barbone M G, Zonta F, Grana E
出版信息
Farmaco Sci. 1983 Nov;38(11):817-25.
PMID:6653769
Abstract
Five new heterocyclic acyl-cholines were synthetized through 1,3-dipolar cycloaddition and their adrenergic, cholinergic and histaminergic activity evaluated. The tested compounds did not show any significant activity; some of them, in particular the isoxazole derivative (X), shift the dose-response curve of norepinephrine to the left.
摘要
通过1,3-偶极环加成反应合成了五种新的杂环酰基胆碱，并对它们的肾上腺素能、胆碱能和组胺能活性进行了评估。所测试的化合物未显示出任何显著活性；其中一些化合物，特别是异恶唑衍生物（X），使去甲肾上腺素的剂量-反应曲线向左移动。
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