Grana E, Zonta F, D'Agostino G
Farmaco Sci. 1980 Dec;35(12):1021-33.
A study has been made of the action on the rat vas deferens response to noradrenalin of the following substances: cocaine, phentolamine and dihydroergocrystine; pronethalol, dichloroisopropylnoradrenalin, propranolol, N-isopropyl-p-nitrophenylethanolamine; d-chlorpheniramine; cimetidine; amitryptyline. With the exception of the beta-adrenolytic agents and cimetidine, all the compounds tested independently of their "principal" pharmacological action showed a property in common with the local anesthetics: depending on dose they were able to increase or decrease the maximal response to noradrenalin. These effects were correlated with variations in the state of stabilization of the membrane.
可卡因、酚妥拉明和二氢麦角隐亭；普萘洛尔、二氯异丙基去甲肾上腺素、心得安、N-异丙基对硝基苯乙醇胺；右旋氯苯那敏；西咪替丁；阿米替林。除β-肾上腺素能阻滞剂和西咪替丁外，所有受试化合物无论其“主要”药理作用如何，均表现出与局部麻醉药共有的一种特性：根据剂量，它们能够增加或降低对去甲肾上腺素的最大反应。这些效应与膜稳定状态的变化相关。
