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具有降压活性的1,3,3-三甲基-6-氮杂双环[3.2.1]辛烷衍生物。II.

Derivatives of 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane with hypotensive activity. II.

作者信息

Ranise A, Bondavalli F, Mariani E, Schenone P, Lampa E, Giordano L, Vacca C, Marmo E

出版信息

Farmaco Sci. 1983 Nov;38(11):884-92.

PMID:6653774
Abstract

The synthesis of a series of alkyl and aryl ureas (II) starting from 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane is described. Some of these compounds showed a moderate hypotensive activity in rats. Effects on heart rate in rats, infiltration anesthesia and antiarrhythmic activity in mice, as well as antiacetylcholine activity in vitro, are also reported.

摘要

描述了从1,3,3-三甲基-6-氮杂双环[3.2.1]辛烷开始合成一系列烷基和芳基脲（II）的过程。其中一些化合物在大鼠中显示出中等程度的降压活性。还报道了其对大鼠心率的影响、在小鼠中的浸润麻醉和抗心律失常活性，以及体外抗乙酰胆碱活性。

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