Longobardi M, Schenone P, Bargagna A, Berrino L, Matera C, Marmo E
Farmaco Sci. 1985 Mar;40(3):152-61.
The synthesis of two series of amides and glycinamides starting from N-phenyl benzonorbornen-2-endo-amine, prepared from benzonorbornen-2-one via sodium borohydride reduction of its N-phenyl imine, is described. Some amides showed a remarkable hypotensive activity in rats, whereas amides and glycinamides usually exhibited a moderate infiltration anesthesia in mice. Effects on heart rate in rats and antiarrhythmic activity in mice are also reported.
描述了从N-苯基苯并降冰片烯-2-内型胺开始合成两个系列的酰胺和甘氨酰胺，该胺由苯并降冰片烯-2-酮通过其N-苯基亚胺的硼氢化钠还原制备。一些酰胺在大鼠中显示出显著的降压活性，而酰胺和甘氨酰胺在小鼠中通常表现出中度浸润麻醉作用。还报道了对大鼠心率的影响和对小鼠的抗心律失常活性。
