Monoclonal antibodies to drugs--digoxin.

A number of monoclonal antibodies to digoxin, two of which have been further characterized, were produced by somatic cell fusion. No cross reactivity with chemically related drugs was detected. Preliminary in vivo studies showed altered digoxin pharmacokinetics in antibody treated mice. These monoclonal antibodies could be used for a standardized radioimmunoassay and in the treatment of digoxin toxicity.