叔丁氧羰基-L-脯氨酰-α-氨基异丁酰-L-丙氨酰-α-氨基异丁酸甲酯的晶体和分子结构
Crystal and molecular structure of tert.-butyloxycarbonyl-L-prolyl-alpha-aminoisobutyryl-L-alanyl-alpha- aminoisobutyrate methyl ester.
作者信息
Van Roey P, Smith G D, Balasubramanian T M, Czerwinski E W, Marshall G R, Mathews F S
出版信息
Int J Pept Protein Res. 1983 Oct;22(4):404-9. doi: 10.1111/j.1399-3011.1983.tb02109.x.
Boc-Pro-Aib-Ala-Aib-OMe crystallizes in the orthorhombic space group P2(1)2(1)2 with cell dimensions a = 17.701 (3) A, b = 17.476 (4) A, c = 9.686 (2) A, V = 2996.3 A3. The first three residues form a single turn of a 3(10)-helix stabilized by two intramolecular hydrogen bonds. Comparison of the conformation of the methyl ester of the tetrapeptide with that of its benzyl ester shows differences in the individual torsion angles of up to 29 degrees, although the overall conformation is conserved.
Boc - Pro - Aib - Ala - Aib - OMe以正交空间群P2(1)2(1)2结晶，晶胞参数a = 17.701 (3) Å，b = 17.476 (4) Å，c = 9.686 (2) Å，V = 2996.3 ų。前三个残基形成一个3(10)-螺旋的单圈，由两个分子内氢键稳定。四肽甲酯与其苄酯的构象比较表明，尽管整体构象保守，但各个扭转角的差异高达29度。
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