Ishiura S, Nonaka I, Fujita T, Sugita H
J Biochem. 1983 Nov;94(5):1631-6.
We have examined the effect of cycloheximide on bupivacaine-induced, macrophage-mediated muscle degeneration in rats and obtained the following results. Direct intramuscular injection of bupivacaine into soleus muscle caused uniform muscle degeneration (Ishiura, S. et al. (1983) J. Biochem. 94, 311-314). The degeneration was most prominent 48 h after injection, with many infiltrating macrophages. Intraperitoneal administration of cycloheximide prevented the bupivacaine-induced macrophage invasion and decrease of structural proteins 48 h after injection. Cycloheximide inhibited the increase in lysosomal enzymes in bupivacaine-treated muscle. The peritoneal macrophages increased in number immediately after bupivacaine injection, while cycloheximide inhibited their accumulation. These results indicated that cycloheximide inhibited muscle degradation by preventing macrophage proliferation.
我们研究了环己酰亚胺对布比卡因诱导的大鼠巨噬细胞介导的肌肉变性的影响，并获得了以下结果。将布比卡因直接肌内注射到比目鱼肌中会导致均匀的肌肉变性（石浦，S.等人（1983年）《生物化学杂志》94卷，311 - 314页）。注射后48小时变性最为明显，有许多浸润的巨噬细胞。腹腔注射环己酰亚胺可防止注射后48小时布比卡因诱导的巨噬细胞浸润和结构蛋白减少。环己酰亚胺抑制布比卡因处理的肌肉中溶酶体酶的增加。布比卡因注射后立即腹膜巨噬细胞数量增加，而环己酰亚胺抑制它们的聚集。这些结果表明，环己酰亚胺通过阻止巨噬细胞增殖来抑制肌肉退化。
