恶性肿瘤中细胞异质性的实验及临床意义
The experimental and clinical implications of cellular heterogeneity in malignant tumors.
作者信息
Poste G, Greig R
出版信息
J Cancer Res Clin Oncol. 1983;106(3):159-70. doi: 10.1007/BF00402602.
Abstract
The growing body of evidence showing that malignant tumors are heterogeneous and contain diverse subpopulations of tumor cells is reviewed, with particular emphasis being given to the presence of tumor-cell subpopulations with differing metastatic properties. The factors that may influence the evolution of cellular diversity at different stages in the progression of malignant neoplasms are discussed. Emphasis is given to the possibility that interactions occurring amongst the constituent subpopulations of a malignant tumor may influence the rate at which new variant subpopulations emerge. Metastatic heterogeneity poses significant problems for experimental efforts to identify features unique to metastatic cells and also for the therapy of metastatic disease.
摘要
本文综述了越来越多的证据，这些证据表明恶性肿瘤具有异质性，包含不同亚群的肿瘤细胞，尤其着重讨论了具有不同转移特性的肿瘤细胞亚群的存在。文中还讨论了可能影响恶性肿瘤进展不同阶段细胞多样性演变的因素。重点强调了恶性肿瘤组成亚群之间发生的相互作用可能会影响新变异亚群出现速度的可能性。转移异质性给识别转移细胞独特特征的实验研究以及转移性疾病的治疗带来了重大问题。
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