Obara T, Kudo K, Watanabe A
Jpn J Antibiot. 1983 Aug;36(8):2142-6.
Clinical effects of cefpiramide (CPM) on 10 respiratory tract infections were excellent in 9 and poor in 1, and those on 3 urinary tract infections were excellent in 3. Although CPM is considered to be excreted mainly into bile, it was suggested that the excretion rate of CPM at doses of 10 approximately 20 mg/kg into urine is good enough. Antibacterial activity of CPM was considered to be almost the same as that of cefmetazole and cefoperazone. As to side effects, weak diarrhea was observed in 2 cases. This should be considered when CPM is given to children because of its main excretion route to bile duct.
头孢匹胺（CPM）对10例呼吸道感染的临床疗效为9例极佳，1例较差；对3例尿路感染的临床疗效为3例均极佳。尽管CPM被认为主要经胆汁排泄，但研究表明，10～20mg/kg剂量的CPM经尿液的排泄率良好。CPM的抗菌活性被认为与头孢美唑和头孢哌酮几乎相同。副作用方面，观察到2例出现轻度腹泻。鉴于CPM主要经胆管排泄，因此给儿童使用时应考虑这一点。
