Terashima I, Nakamura A, Okimoto Y, Kurosaki T, Himi K, Uehara S
Jpn J Antibiot. 1983 Aug;36(8):2171-6.
Cefpiramide (CPM) was given to 4 patients with respiratory tract infection (H. influenzae 3 cases, P. aeruginosa 1 case), 1 patient with enteritis (enteropathogenic E. coli) and 1 patient with sepsis (E. cloacae). Bacteriological eradication was observed in 5 cases (83.3%), and clinical effectiveness was 66.7%. Serum concentration of CPM at a dose of 15 mg/kg after intravenous drip-infusion for 30 minutes was 105 micrograms/ml at the end of infusion and 67 micrograms/ml at 1 hour. Bacteriological eradication by the administration of CPM was rapidly occurred in 3 strains of H. influenzae including 1 strain of beta-lactamase producing ABPC-resistant one, and 1 strain of P. aeruginosa in the sputum. One patient aged 2 years and 5 months with pneumonia was cured by the treatment of CPM as an outpatient. No side effects were observed except 1 case of vascular pain. It was concluded that CPM is a useful drug for the treatment of bacterial infections in children.
给4例呼吸道感染患者（流感嗜血杆菌3例、铜绿假单胞菌1例）、1例肠炎患者（致病性大肠杆菌）和1例败血症患者（阴沟肠杆菌）使用头孢匹胺（CPM）。5例（83.3%）观察到细菌学清除，临床有效率为66.7%。静脉滴注30分钟后给予15mg/kg剂量的CPM，输注结束时血清浓度为105μg/ml，1小时时为67μg/ml。在痰液中的3株流感嗜血杆菌（包括1株产β-内酰胺酶的耐氨苄青霉素菌株）和1株铜绿假单胞菌中，给予CPM后迅速出现细菌学清除。1例2岁5个月的肺炎患儿门诊接受CPM治疗后治愈。除1例血管疼痛外，未观察到副作用。结论是CPM是治疗儿童细菌感染的有效药物。
