Fujita K, Sakata H, Murono K, Mukai N, Yoshioka H, Maruyama S, Sanae N, Tsuchida A, Suzuki Y
Jpn J Antibiot. 1983 Aug;36(8):2135-41.
Thirty-six febrile patients were administered cefpiramide (CPM) of 20 approximately 75 mg/kg/day for 3 approximately 11 days, and the clinical and side effects were evaluated. Among children with bacterial infections, including pneumonia, urinary tract infection, sepsis, pharyngitis and bronchitis, the results were excellent in 9, good in 13, and fair in 3 patients. Out of 36 patients, adverse reactions were observed in 9 cases, i.e. vascular pain at one shot intravenous injection in 4, diarrhea in 2, eosinophilia in 2, and diarrhea and eosinophilia in 1 case. One shot intravenous administration of CPM of 10 mg/kg to 4 patients yielded mean serum level of 100 micrograms/ml at 15 minutes and mean serum half-life of 2.5 hours, and administration of 20 mg/kg to 3 patients yielded mean serum level of 200 micrograms/ml at 15 minutes and mean serum half-life of 3.5 hours. The half-life in 1 patient with slight liver lesion was 5.36 hours. The rates of urinary recovery within 8 approximately 12 hours were 7.2 to 28.0% in 5 patients, 45.1% in a patient with nephrotic syndrome, and 50.9% in a patient with slight liver lesion.
对36例发热患者给予头孢匹胺（CPM），剂量约为20～75mg/kg/天，疗程3～11天，并对临床疗效和副作用进行评估。在患有细菌感染的儿童中，包括肺炎、尿路感染、败血症、咽炎和支气管炎，9例效果极佳，13例良好，3例一般。36例患者中，9例出现不良反应，即4例单次静脉注射时出现血管疼痛，2例腹泻，2例嗜酸性粒细胞增多，1例腹泻合并嗜酸性粒细胞增多。对4例患者单次静脉注射10mg/kg的CPM，15分钟时血清平均水平为100μg/ml，血清平均半衰期为2.5小时；对3例患者单次静脉注射20mg/kg，15分钟时血清平均水平为200μg/ml，血清平均半衰期为3.5小时。1例轻度肝损害患者的半衰期为5.36小时。5例患者在8～12小时内的尿回收率为7.2%～28.0%，1例肾病综合征患者为45.1%，1例轻度肝损害患者为50.9%。
