Lamprecht J, Lamprecht A, Morgenstern C
Laryngol Rhinol Otol (Stuttg). 1983 Nov;62(11):499-501.
The authors observe an increasing incidence of multiple primary neoplasms in the upper aerodigestive tract. Out of 1231 patients with neoplasms, 110 (= 8.9%) developed another tumour. Following oral cavity tumours the incidence of second tumours was twice as high as in other localities. Privileged site of second tumours following cancer of the larynx is the lung, after oral cavity neoplasms the hypopharynx and larynx. The mean interval between first and secondary neoplasms was 4.4 years. In tumour follow-up therapy it is recommended to look not only for relapses and metastases but also for second tumours.
作者观察到上呼吸消化道多原发性肿瘤的发病率呈上升趋势。在1231例肿瘤患者中，110例（8.9%）发生了另一种肿瘤。继口腔肿瘤之后，第二种肿瘤的发病率是其他部位的两倍。喉癌之后第二种肿瘤的好发部位是肺，口腔肿瘤之后是下咽和喉。原发性肿瘤与继发性肿瘤之间的平均间隔时间为4.4年。在肿瘤后续治疗中，建议不仅要查找复发和转移情况，还要查找第二种肿瘤。
