Enser M, Ashwell M
Lipids. 1983 Nov;18(11):776-80. doi: 10.1007/BF02534635.
The subcutaneous adipose tissue of genetically obese mice (ob/ob) differs from that of lean littermates not only by virtue of its larger cells but also in its fatty acid composition; it contains a higher proportion of palmitoleic acid and a lower proportion of linoleic acid. To determine whether these differences in fatty acid composition were inherent in fat cells, subcutaneous adipose tissue from obese and lean mice was transplanted under the kidney capsules of lean and obese host mice and the fatty acid composition of the neutral lipids of the graft and of the host perirenal and subcutaneous fat was determined 1 or 2 months later. The fatty acid composition of grafts from lean donors in obese mice resembled that of the perirenal adipose tissue of the obese hosts after 1 month, with a lower proportion of linoleic acid and a higher proportion of palmitoleic acid than in lean mice. Grafts from obese mice in lean mice had fatty acid compositions which were either unchanged, partially changed or which completely resembled that of the host. The use of grafts prelabeled by feeding the donor margaric acid indicated that total lack of fatty acid turnover, rather than selective metabolic processes, was responsible for the failure of some grafts from obese mice in lean mice to acquire the fatty acid composition of the perirenal adipose tissue of the host.
基因肥胖小鼠（ob/ob）的皮下脂肪组织不仅因其细胞较大，而且在脂肪酸组成上也与瘦的同窝小鼠不同；它含有较高比例的棕榈油酸和较低比例的亚油酸。为了确定这些脂肪酸组成的差异是否存在于脂肪细胞中，将肥胖和瘦小鼠的皮下脂肪组织移植到瘦和肥胖宿主小鼠的肾包膜下，并在1或2个月后测定移植脂肪以及宿主肾周和皮下脂肪中性脂质的脂肪酸组成。肥胖小鼠中来自瘦供体的移植脂肪在1个月后的脂肪酸组成类似于肥胖宿主的肾周脂肪组织，与瘦小鼠相比，亚油酸比例较低，棕榈油酸比例较高。瘦小鼠中来自肥胖小鼠的移植脂肪的脂肪酸组成要么没有变化，要么部分改变，要么完全类似于宿主。通过给供体喂食十七烷酸对移植脂肪进行预标记表明，一些瘦小鼠中来自肥胖小鼠的移植脂肪未能获得宿主肾周脂肪组织的脂肪酸组成，原因是完全缺乏脂肪酸周转，而非选择性代谢过程。
