Obesity: can some fat cells enlarge while others are shrinking?

CBA mice were made obese by injection with gold thioglucose (GTG). After receiving transplants of "lean" and "GTG-obese" fat under separate kidney capsules, the host mice were fed a restricted diet for three weeks. Over this period, the fat cells in the lean grafts enlarged whereas the fat cells in the GTG-obese grafts shrank. Concurrent fat loss and fat gain can therefore take place.