Reinharez D
Phlebologie. 1983 Oct-Dec;36(4):337-44.
After discussing the psychological importance of the problem, the author stresses that the best treatment of pigmentations after sclerosis is prevention, based on experience and faultless technique (careful choice of sclerosants, local compression, evacuation of thrombi). The author then briefly reviews the pathophysiology of melanin dyschromias and their causes and presents the histological finding of a mixed origin for post-sclerosis pigmentations (melanin and iron). Various attempts at treatment are presented. The most effective form of treatment seems to be the percutaneous application of a mixture consisting of : -an iron chelator (desferoxamine), -an anti-inflammatory (alpha-chymotrypsin), -an anti-melanin agent (mequinol).
在讨论了该问题的心理重要性之后,作者强调,基于经验和完善的技术(仔细选择硬化剂、局部压迫、血栓清除),硬化后色素沉着的最佳治疗方法是预防。作者随后简要回顾了黑色素色素沉着异常的病理生理学及其成因,并展示了硬化后色素沉着(黑色素和铁)混合起源的组织学发现。文中介绍了各种治疗尝试。最有效的治疗方式似乎是经皮应用一种由以下成分组成的混合物:- 一种铁螯合剂(去铁胺),- 一种抗炎药(α-糜蛋白酶),- 一种抗黑色素剂(甲萘醌)。