Iannotti F, Hoff J
Stroke. 1983 Jul-Aug;14(4):562-7. doi: 10.1161/01.str.14.4.562.
Tissue water and rCBF from the same area of brain was measured in gerbils with cerebral ischemia. In one experiment we related the severity of ischemia that developed after one hour of carotid occlusion to the amount of edema which formed. In a second experiment brain made ischemic for one hour was reperfused for one hour to assess the effect of reperfusion of ischemic tissue upon edema formation. We identified a critical threshold (10-14 ml X 100g-1 min-1) for the reversibility of the ischemic process, above which edema can resolve upon reperfusion. When postocclusion rCBF was less than 10 ml X 100g-1 min-1, edema was maximal at the end of occlusion and did not resolve with reperfusion. Autoregulation was preserved in ischemic tissue in which the edema process resolved with reperfusion.
在患有脑缺血的沙鼠中，测量了来自大脑同一区域的组织水和局部脑血流量（rCBF）。在一项实验中，我们将颈动脉闭塞1小时后发生的缺血严重程度与形成的水肿量相关联。在第二项实验中，使大脑缺血1小时，然后再灌注1小时，以评估缺血组织再灌注对水肿形成的影响。我们确定了缺血过程可逆性的临界阈值（10 - 14毫升×100克⁻¹×分钟⁻¹），高于此阈值，水肿可在再灌注时消退。当闭塞后rCBF小于10毫升×100克⁻¹×分钟⁻¹时，水肿在闭塞结束时最大，并且不会随着再灌注而消退。在水肿过程随着再灌注而消退的缺血组织中，自动调节功能得以保留。
