Naritomi H
Stroke. 1983 Mar-Apr;14(2):213-8. doi: 10.1161/01.str.14.2.213.
To assess the effect of supratentorial cerebral ischemia on infratentorial brain function, changes in regional cerebellar blood flow (rCeBF), after right carotid occlusion for 4 hours, were studied in 30 mongolian gerbils. The regional cerebral blood flow (rCBF) in the occluded cerebral hemisphere and rCeBF in both cerebellar hemispheres were measured simultaneously by hydrogen clearance methods. Before carotid occlusion, rCBF was 0.44 +/- 0.07 ml/g brain/min, and rCeBF in the left and right cerebellar hemispheres was 0.37 +/- 0.09 and 0.40 +/- 0.09 ml/g brain/min, respectively. After carotid occlusion, rCBF decreased in all animals showing levels of above 0.20 ml/g brain/min in 14 (group A), between 0.10 and 0.19 ml/g brain/min in 7 (group B) and below 0.10 ml/g brain/min in 9 (group C). rCeBF exhibited no changes in group A and a mild reduction in group B after carotid occlusion. In group C, rCeBF was significantly reduced 30 min after carotid occlusion in the left cerebellar hemisphere followed subsequently by bilateral reduction. In groups B and C, supratentorial brain edema was observed 4 hours after occlusion, but the degree of edema was moderate. The results of the present study suggest that depression of infratentorial brain function may occur after supratentorial local cerebral ischemia, presumably due to diaschisis.
为评估幕上脑缺血对幕下脑功能的影响，对30只蒙古沙鼠进行了研究，观察右侧颈动脉闭塞4小时后小脑局部血流（rCeBF）的变化。采用氢清除法同时测量闭塞脑半球的局部脑血流（rCBF）和双侧小脑半球的rCeBF。颈动脉闭塞前，rCBF为0.44±0.07ml/g脑/分钟，左、右小脑半球的rCeBF分别为0.37±0.09和0.40±0.09ml/g脑/分钟。颈动脉闭塞后，所有动物的rCBF均下降，其中14只（A组）rCBF水平高于0.20ml/g脑/分钟，7只（B组）在0.10至0.19ml/g脑/分钟之间，9只（C组）低于0.10ml/g脑/分钟。颈动脉闭塞后，A组rCeBF无变化，B组有轻度降低。在C组，颈动脉闭塞30分钟后左小脑半球rCeBF显著降低，随后双侧降低。在B组和C组中，闭塞4小时后观察到幕上脑水肿，但水肿程度为中度。本研究结果表明，幕上局部脑缺血后可能会发生幕下脑功能抑制，推测是由于交叉性小脑神经机能联系失能所致。
