慢性阻塞性肺疾病患者的流感疫苗接种与茶碱药代动力学
Influenza vaccination and theophylline pharmacokinetics in patients with chronic obstructive lung disease.
作者信息
Stults B M, Hashisaki P A
出版信息
West J Med. 1983 Nov;139(5):651-4.
Abstract
Total Theophylline clearance rate was measured before and 24 hours after standard influenza vaccination in seven men with stable chronic obstructive lung disease. In four, total theophylline clearance rate was also measured 48 hours after vaccine administration. There was no significant change in the clearance rate after either time interval. These results do not support recent recommendations to monitor serum theophylline concentrations or reduce theophylline dosage during the 48-hour period following influenza vaccination. Nevertheless, pending further studies, patients maintained on a regimen of theophylline preparations should be followed clinically for theophylline toxicity for the first several days after receiving influenza vaccine.
摘要
在7名患有稳定型慢性阻塞性肺疾病的男性中，在标准流感疫苗接种前及接种后24小时测量了总茶碱清除率。其中4人还在疫苗接种后48小时测量了总茶碱清除率。在这两个时间间隔后，清除率均无显著变化。这些结果不支持最近关于在流感疫苗接种后48小时内监测血清茶碱浓度或降低茶碱剂量的建议。尽管如此，在进一步研究之前，接受茶碱制剂治疗的患者在接种流感疫苗后的头几天应进行临床随访，以监测茶碱毒性。
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