Graziani G, de Vecchi A, Ponticelli C
Proc Eur Dial Transplant Assoc. 1975;11:277-83.
Urinary acid excretion was measured in 35 human renal allograft recipients during the first few days after the onset of diuresis and two months after transplantation. In 16 out of 17 rejection episodes an early significant decrease of renal total net H+ excretion was observed. This urinary acidification impairment preceded the serum creatinine increase. Only few patients showed variations in blood pH and C1-. The acidification defect may be due to the ischaemic changes of rejection. Early impairment of urinary acidification supports a clinical diagnosis of rejection.
在35例人类肾移植受者利尿开始后的最初几天以及移植后两个月，测量了尿酸排泄情况。在17次排斥反应中的16次中，观察到肾脏总净氢离子排泄早期显著减少。这种尿酸化损害先于血清肌酐升高出现。只有少数患者的血液pH值和氯离子有变化。酸化缺陷可能是由于排斥反应的缺血性改变所致。尿酸化的早期损害支持排斥反应的临床诊断。
